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A Y1R germline deletion results in elevated osteoblast activity and mineral apposition rate, together with increased formation of highly multinucleated osteoclasts and enhanced surface area, demonstrating a negative role of Y1R on bone mass maintenance [76]

IBS and GLP-1: What the Clinical Evidence Shows Recent data suggests that GLP-1 therapy does not worsen IBS in most patients when dosing is managed carefully

Some individuals carry genetic patterns associated with stronger initial GLP-1 response but faster adaptation, while others show gradual but steady progress over months